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fist (fĭst)n.1. The hand closed tightly with the fingers bent against the palm.2. Informal A grasp; a clutch: had a fortune in their fists and let it go.tr.v. fist·ed, fist·ing, fists 1. To clench into a fist.2. To grasp with the fist.3. Vulgar To insert the hand into the rectum or vagina of (someone) as a means of sexual stimulation.[Middle English, from Old English fȳst; see penkwe in Indo-European roots.]