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drain  (drān)v. drained, drain·ing, drains v.tr.1. To draw off (a liquid) by a gradual process: drained water from the sink.2. a. To cause liquid to go out from; empty: drained the bathtub; drain the pond.b. To draw off the surface water of: The Mississippi River drains a vast area.3. To drink all the contents of: drained the cup.4. a. To cause (a resource or supply of something) to be used up gradually and often completely. See Synonyms at deplete.b. To fatigue or spend emotionally or physically: The day's events drained me of energy.5. Sports To put (a ball or shot) into a hole or basket, as in golf or basketball: drained the putt for a birdie.v.intr.1. To flow off or out: Gasoline drained slowly from the tilted can.2. To become empty by the drawing off of liquid: watched the tub slowly drain.3. To discharge surface or excess water: The Niagara River drains into Lake Ontario. When flooded, the swamp drains northward.4. To become gradually depleted; dwindle: felt his enthusiasm draining.n.1. A pipe or channel by which liquid is drawn off.2. Medicine A device, such as a tube, inserted into the opening of a wound or body cavity to facilitate discharge of fluid or purulent material.3. The act or process of draining.4. a. A gradual outflow or loss; cons