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poi·son (poi′zən)n.1. A substance that causes injury, illness, or death, especially by chemical means.2. Something destructive or fatal.3. Chemistry A substance that inhibits another substance or a reaction: a catalyst poison.tr.v. poi·soned, poi·son·ing, poi·sons 1. To kill or harm with poison.2. To put poison on or into: poisoning arrows; poisoned the drink.3. a. To pollute: Noxious fumes poison the air. See Synonyms at contaminate.b. To have a harmful influence on; corrupt: Jealousy poisoned their friendship.4. Chemistry & Physics To inhibit (a substance or reaction).adj. Poisonous.[Middle English, from Old French, from Latin pōtiō, pōtiōn-, drink; see pō(i)- in Indo-European roots.]poi′son·er n.