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al·ler·gy (ăl′ər-jē)n. pl. al·ler·gies 1. An abnormally high sensitivity to certain substances, such as pollens, foods, or microorganisms. Common indications of allergy may include sneezing, itching, and skin rashes.2. Informal An adverse sentiment; antipathy: an allergy to cocktail parties.[German Allergie : Greek allos, other; see allo- + Greek ergon, action; see werg- in Indo-European roots.]