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vac·cine (văk-sēn′, văk′sēn′)n.1. a. A preparation of a weakened or killed pathogen, such as a bacterium or virus, or of a portion of the pathogen's structure that upon administration to an individual stimulates antibody production or cellular immunity against the pathogen but is incapable of causing severe infection.b. A preparation from the cowpox virus that protects against smallpox when administered to an individual.2. Computers A software program designed to detect and stop the progress of computer viruses.[From Latin vaccīnus, of cows, from vacca, cow.]