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mastiffmas·tiff (măs′tĭf)n. A dog of a large powerful breed developed in England as a guard dog, having a large head, short black muzzle, and short often fawn-colored coat.[Middle English mastif, alteration (perhaps influenced by Old French mestif, mongrel) of Old French mastin, from Vulgar Latin *(canis) mānsuētīnus, tame (dog), from Latin mānsuētus, past participle of mānsuēscere, to tame : manus, hand; see man- in Indo-European roots + suēscere, to accustom; see s(w)e- in Indo-European roots.]