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vac·uum (văk′yo͞om, -yəm, -yo͞o-əm)n. pl. vac·uums or vac·u·a (-yo͞o-ə) 1. a. Absence of matter.b. A space empty of matter.c. A space relatively empty of matter.d. A space in which the pressure is significantly lower than atmospheric pressure.2. A state of emptiness; a void.3. A state of being sealed off from external or environmental influences; isolation.4. pl. vac·uums A vacuum cleaner.adj.1. Of, relating to, or used to create a vacuum.2. Containing air or other gas at a reduced pressure.3. Operating by means of suction or by maintaining a partial vacuum.tr. & intr.v. vac·uumed, vac·uum·ing, vac·uums To clean with or use a vacuum cleaner.[Latin, empty space, from neuter of vacuus, empty, from vacāre, to be empty; see euə- in Indo-European roots.]